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|Título:||The mammary gland in domestic ruminants : a systems biology perspective|
|Autor:||Ferreira, Ana M.|
Bislevc, Stine L.
Almeida, André M.
|Citação:||Ferreira, A.M., Bislevc, S.L., Bendixenc, E., Almeida, A.M. (2013). The mammary gland in domestic ruminants : a systems biology perspective. Journal of Proteomics, 9(4), 110-123. doi: 10.1016/j.jprot.2013.09.012|
|Resumo:||Milk and dairy products are central elements in the human diet. It is estimated that 108 kg of milk per year are consumed per person worldwide. Therefore, dairy production represents a relevant fraction of the economies of many countries, being cattle, sheep, goat, water buffalo, and other ruminants the main species used worldwide. An adequate management of dairy farming cannot be achieved without the knowledge on the biological mechanisms behind lactation in ruminants. Thus, understanding the morphology, development and regulation of the mammary gland in health, disease and production is crucial. Presently, innovative and high-throughput technologies such as genomics, transcriptomics, proteomics and metabolomics allow a much broader and detailed knowledge on such issues. Additionally, the application of a systems biology approach to animal science is vastly growing, as new advances in one field of specialization or animal species lead to new lines of research in other areas or/and are expanded to other species. This article addresses how modern research approaches may help us understand long-known issues in mammary development, lactation biology and dairy production. Biological significance Dairy production depends upon the knowledge of the morphology and regulation of the mammary gland and lactation. High-throughput technologies allow a much broader and detailed knowledge on the biology of the mammary gland. This paper reviews the major contributions that genomics, transcriptomics, metabolomics and proteomics approaches have provided to understand the regulation of the mammary gland in health, disease and production. In the context of mammary gland “omics”-based research, the integration of results using a Systems Biology Approach is of key importance.|
|Descrição:||Articles in International Journals|
|Versão do Editor:||http://www.sciencedirect.com/science/article/pii/S1874391913004788|
|Aparece nas colecções:||CIISA - Artigos em revistas internacionais|
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