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|Title: ||Body Composition and metabolic syndrome features in overweight and obese women|
|Authors: ||Rocha, Paulo Manuel Espadinha Pinheiro da|
|Advisor: ||Sardinha, Luis Fernando Cordeiro Bettencourt|
|Keywords: ||Adipose tissue|
Factores de risco
|Issue Date: ||16-Feb-2007|
|Abstract: ||This thesis sought to analyze the relationships between body composition
markers and metabolic syndrome features in overweight and obese women, being
structured in three scientific problems.
The first scientific problem investigated the separate contributions of waist
and hip circumference to proinflammatory and atherothrombotic metabolic syndrome disturbances. Associations of thigh adipose and muscle tissue compartments with metabolic features were also studied. For a given waist
circumference, a larger hip circumference predicted a lower diabetogenic and
atherothrombotic risk. Femoral-gluteal adipose tissue seems to mediate this
The second problem studied the independent associations of abdominal and thigh adipose tissue compartments with metabolic syndrome clinical features.
Contrarily to visceral adipose tissue, a larger thigh subcutaneous adipose tissue was
related with a lower thrombotic and atherogenic risk.
The last problem analyzed the independent relations of abdominal and thigh adipose
tissue compartments with liver fat. The associations of proinflammatory and
atherothrombotic risk factors with liver fat were also studied. Thigh subfascial
adipose tissue was inversely associated with liver fat, suggesting that this thigh fat depot may play a protective role against ectopic liver fat storage. An abdominal obesity phenotype associated with a diabetogenic, inflammatory, and
atherothrombotic metabolic profile may to contribute to liver lipotoxicity.|
|Description: ||Tese de Doutoramento em Motricidade Humana na especialidade de Saúde e Condição Física|
|Appears in Collections:||EXS - Teses de Doutoramento|
BFMH - Teses de Doutoramento / Ph.D.Thesis
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