Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.5/7310
Título: Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle
Autor: Murta, Daniel
Batista, Marta
Silva, Elisabete
Trindade, Alexandre
Henrique, Domingos
Duarte, António
Lopes da Costa, Luís
Palavras-chave: Germ cells
Immunostaining
Notch signaling
Sertoli cells
Spermatids
Spermatocytes
Spermatogenesis
Spermatogonia
Data: 28-Ago-2013
Editora: Jean-Marc A. Lobaccaro, Clermont Université , France
Citação: Murta, D., Batista, M., Silva, E., Trindade, A., Henrique, D., Duarte, A. et al. (2013). Dynamics of Notch Pathway Expression during Mouse Testis Post-Natal Development and along the Spermatogenic Cycle. PLoS ONE 8(8): e72767. doi:10.1371/journal.pone.0072767
Resumo: The transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key moments of post-natal development, and along the adult spermatogenic cycle. Notch pathway components and effectors are transcribed in the testis and expressed in germ, Sertoli and Leydig cells, and each Notch component shows a specific cell-type and timewindow expression pattern. This expression at key testis developmental events prompt for a role of Notch signaling in prepubertal spermatogonia quiescence, onset of spermatogenesis, and regulation of the spermatogenic cycle.
Descrição: Articles in International Journals
Peer review: yes
URI: http://hdl.handle.net/10400.5/7310
DOI: 10.1371/journal.pone.0072767
ISSN: 1932-6203 (online)
Versão do Editor: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0072767
Aparece nas colecções:DMF - Artigos de revista
DC - Artigos de revista
CIISA - Artigos em revistas internacionais



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