Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.5/7211
Título: Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation
Autor: Gil, S.
Leal, R.O.
McGahie, D.
Sepúlveda, N.
Duarte, A.
Niza, M.M.R.E.
Tavares, L.
Palavras-chave: Feline Immunodeficiency Virus (FIV)
Recombinant-Feline Interferon Omega (rFeIFN-ω)
Immune-modulation
Oral therapy
Data: Fev-2014
Editora: Elsevier Ltd.
Citação: Gil, S., et al. (2014). Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation. Research in Veterinary Science, 96(1), 79–85. doi: 10.1016/j.rvsc.2013.11.007
Resumo: Recombinant-Feline Interferon-Omega (rFeIFN-ω) is an immune-modulator licensed for use subcutaneously in Feline Immunodeficiency virus (FIV) therapy. Despite oral protocols have been suggested, little is known about such use in FIV-infected cats. This study aimed to evaluate the clinical improvement, laboratory findings, concurrent viral excretion and acute phase proteins (APPs) in naturally FIV-infected cats under oral rFeIFN-ω therapy (0.1 MU/cat rFeIFN-ω PO, SID, 90 days). 11 FIV-positive cats were treated with oral rFeIFN-ω (PO Group). Results were compared to previous data from 7 FIV-positive cats treated with the subcutaneous licensed protocol (SC Group). Initial clinical scores were similar in both groups. Independently of the protocol, rFeIFN-ω induced a significant clinical improvement of treated cats. Concurrent viral excretion and APP’s variation were not significant in the PO Group. Oral rFeIFN-ω can be an effective alternative therapy for FIV-infected cats, being also an option for treatment follow-up in cats submitted to the licensed protocol.
Descrição: Articles in International Journals
Peer review: yes
URI: http://hdl.handle.net/10400.5/7211
DOI: 10.1016/j.rvsc.2013.11.007
ISSN: 0034-5288
Aparece nas colecções:DSA - Artigos de revista
DC - Artigos de revista
CIISA - Artigos em revistas internacionais



FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.