Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.5/7210
Título: Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter
Autor: Gil, Solange
Leal, Rodolfo O.
Duarte, Ana
McGahie, David
Sepúlveda, Nuno
Siborro, Inês
Cravo, Joana
Cartaxeiro, Clara
Tavares, Luís M.
Palavras-chave: Feline immunodeficiency virus
Feline Leukemia Virus
Interferon
Therapy
Shelter
Feline herpesvirus
Feline coronavirus
Feline calicivirus
Data: Jun-2013
Editora: Elsevier Ltd.
Citação: Gil, S., et al. (2013). Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter. Research in Veterinary Science 94(3), 753–763. doi: 10.1016/j.rvsc.2012.09.025
Resumo: Feline Immnunodeficiency (FIV) and Feline Leukemia (FeLV) viruses are common infectious agents in stray cats and shelter environments. Recombinant feline interferon-x (rFeIFNx) has shown an antiviral action not only against FIV and FeLV but also against herpesvirus (FHV-1) and calicivirus (FCV). Sixteen naturally infected FIV/FeLV cats were followed during rFeIFNx therapy in order to monitor clinical signs and to correlate with excretion of concomitant viruses (FCV, FHV-1, feline coronavirus (FCoV) and parvovirus (FPV)). Cats were submitted to clinical evaluations and concomitant virus excretion assessement. Comparing D0–D65, 10/16 cats improved clinical scores. Of the 10 cats positive for FHV-1 on D0, 4 were negative and 6 reduced viral loads. Of the 11 FCoV positive cats, 9 reduced viral loads. The 13 FCV positive cats and the FPV positive cat were negative on D65. In conclusion, rFeIFNx improves clinical signs and reduces concurrent viral excretion in naturally infected retroviral cats.
Descrição: Articles in International Journals
Peer review: yes
URI: http://hdl.handle.net/10400.5/7210
DOI: 10.1016/j.rvsc.2012.09.025
ISSN: 0034-5288
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CIISA - Artigos em revistas internacionais



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