Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.5/7196
Título: Role of tumor necrosis factor-α, interferon-γ and Fas-ligand on in vitro nitric oxide activity in the corpus luteum
Autor: Galvão, A.M.
Szóstek, Anna Z.
Skarzynski, Dariusz J.
Ferreira-Dias, Graça M.
Palavras-chave: TNF-α
IFN-γ
Fas-ligand
Nitric oxide
Corpus luteum
Data: Out-2013
Editora: Elsevier Ltd.
Citação: Galvão, A.M., Szóstek, A.Z., Skarzynski, D.J., & Ferreira-Dias, G.M. (2013). Role of tumor necrosis factor-x, interferon-y and Fas-ligand on in vitro nitric oxide activity in the corpus luteum. Cytokine, 64(1), 18–21. doi: 10.1016/j.cyto.2013.07.015
Resumo: Normal reproductive function involves the expression of inflammatory mediators. Regarding the corpus luteum (CL), cytokines promote the cross-talk between immune, vascular and steroidogenic cells, among others. Moreover, TNF, IFNG and FASL were shown to regulate equine CL establishment and regression. We hypothesized that cytokines action on equine CL may be mediated by nitric oxide (NO), through the regulation of endothelial NO synthase (eNOS) expression. TNF increased eNOS mRNA level and NO metabolite (nitrite) production during CL growth. Cytokines combined action (TNF + IFNG + FASL) promoted eNOS protein upregulation in mid-CL and nitrite production in mid and late-CL. However, in late-CL, TNF alone decreased nitrite secretion. These results indicate that in equine CL, cytokines TNF, IFNG and FASL regulate NO activity, via eNOS expression modulation.
Descrição: Articles in International Journals
URI: http://hdl.handle.net/10400.5/7196
DOI: 10.1016/j.cyto.2013.07.015
ISSN: 1043-4666
Aparece nas colecções:DMF - Artigos de revista
CIISA - Artigos em revistas internacionais



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