Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.5/7180
Título: Understanding regeneration through proteomics
Autor: Franco, Catarina
Soares, Renata
Pires, Elisabete
Koci, Kamila
Almeida, André M.
Santos, Romana
Coelho, Ana Varela
Palavras-chave: Animal models
Tissue regeneration
Data: Fev-2013
Editora: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Citação: Franco, C., et al. (2013). Understanding regeneration through proteomics. Proteomics, 13(3-4), 686–709. doi: 10.1002/pmic.201200397
Resumo: Regeneration is a complex cellular process that, rather than simply forming a scar following injury, the animal forms a new functional tissue. Regeneration is a widespread process among metazoa, although not uniformly. Planaria, starfish, and some worms can regenerate most of their body, whereas many other species can only regenerate parts of specific tissues or fail to accomplish a functional regrowth, as is the case of mammals CNS. Research in regenerative medicine will possibly culminate in the regeneration of organs/tissues originally not prone to this process. Despite the complexity of the interactions and regulatory systems involved, the variety of tissues and organs these cells differentiate into has so far impaired the success of direct transplantation to restore damaged tissues. For this reason, a study, at the molecular level of the regeneration mechanisms developed by different animal models is likely to provide answers to why these processes are not readily activated in mammals. Proteomic-based approaches are being recognized as extremely useful to study of regeneration events, also because there is a relevant contribution of posttranscriptional processes that involve frequently the occurrence of a broad range of PTMs. The present review focuses on the significant knowledge brought up by proteomics in diverse aspects of regeneration research on different animal models, tissues, and organs.
Descrição: Articles in International Journals
Peer review: yes
URI: http://hdl.handle.net/10400.5/7180
DOI: 10.1002/pmic.201200397
ISSN: 1615-9861 (Online)
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1002/pmic.201200397/abstract
Aparece nas colecções:CIISA - Artigos em revistas internacionais

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