Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.5/7045
Título: Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?
Autor: Galvão, António
Rebordão, Maria Rosa
Szóstek, Anna Z.
J. Skarzynski, Dariusz
Ferreira-Dias, Graça
Palavras-chave: Neutrophil extracellular traps
Data: Jan-2012
Editora: Pferdeheilkunde
Citação: Galvão, António ... [et al.]. 2012. Cytokines and neutrophil extracellular traps and in the equine endometrium: friends or foes?. Pferdeheilkunde, 28 (1):4-7
Resumo: Cytokines may play a dual role in the reproductive tract – either involved in physiologic processes or mediating inflammation and other pathologic processes. Physiologic secretory and angiogenic function in the equine endometrium appears to be regulated by cytokines TNFa, FasL, IFNg through their receptors. These receptors are present in glandular epithelium, and stroma cells and their mRNA expression changes throughout the estrous cycle. Besides, interleukins (IL-1a and IL-1b) and their receptors mRNA expression vary according to various degrees of endometrium inflammation (endometritis) and fibrosis (endometrosis). A novel paradigm in innate immunity and neutrophils (PMN) hyperactivation is PMN ability to cast out their DNA in response to infectious stimuli. These PMN extracellular traps (NETs) bind and kill pathogens, at the infection site. The intriguing dilemma is that even though NETs may function as a first line of defense, they also release molecules that may contribute to tissue damage. Thus, we postulate that PMN present in the endometrium at estrus, mating or infection, might form NETs, and release nucleic and cytoplasmic proteins with immunomodulatory properties. Equine PMN stimulated in vitro showed NETs formation capacity when in contact with some bacteria strains obtained from mares with endometritis, such as Streptococcus zooepidemicus, Escherichia coli and Staphylococus capitis. In this regard, even though NETs and cytokines function as an effective antimicrobial first line of defense or modulate physiologic endometrial function, respectively (friends), they may also be involved in endometrial fibrosis pathogenesis and endometrial secretory function impairment, due to enhanced NETs formation and/or a decrease on NETs degradation (foes).
Descrição: Articles in International Journals
Peer review: yes
URI: http://hdl.handle.net/10400.5/7045
ISSN: 0177-7726
Versão do Editor: http://www.hippiatrika.com/download.htm?id=en20120101
Aparece nas colecções:DMF - Artigos de revista
CIISA - Artigos em revistas internacionais

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